Cardiovascular Medications in Pregnancy


Cardiovascular Medications in Pregnancy, Anti-Arrhythmic Medications in Pregnancy

  • Background
  1. Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S.
    1. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425317.htm
    2. Although FDA Pregnancy Categories are no longer designated, they are included here
      1. As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking
  • Class B
  • No risk in controlled animal studies
  • Class C
  • Small risk in controlled animal studies
  • Class D
  • Strong evidence of risk to the human fetus
  • Class X
  • Very high risk to the human fetus
  1. HMG CoA Reductase Inhibitors (Statins)
    1. Fluvastatin
    2. Lovastatin
    3. Pravastatin
    4. Simvastatin
  • References
  1. Briggs (1998) Drugs in Pregnancy and Lactation, 5th ed
  2. Larimore (2000) Prim Care 27(1):35-53 [PubMed]