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Bumetanide

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Bumetanide, Bumex

  • See Also
  1. Loop Diuretics
  • Indications
  1. See Loop Diuretic
  • Mechanism
  1. See Loop Diuretic
  • Dosing
  • Adults
  1. Background
    1. Bumetanide 1 mg is equivalent to 40 mg Furosemide
  2. Oral
    1. Start: 0.5 to 1 mg orally twice daily
    2. Maximum: 10 mg/day
    3. Onset <1 hour
    4. Half-Life 1.5 hours
    5. Duration: 4-6 hours
  3. Intravenous or Intramuscular
    1. Start: 1 mg IV/dose over 1 to 2 minutes
    2. May repeat 0.5 to 1 mg IV every 2 to 3 hours as needed
    3. Maximum: 4-8 mg/dose
    4. Onset: Within minutes if IV (within 40 minutes if IM)
    5. Duration: 3 to 6 hours
  4. Intravenous Infusion
    1. Load: 1 mg IV
    2. Rate: 0.5 to 2 mg/hour IV
  • Adverse Effects
  1. See Loop Diuretic
  • Safety
  1. Pregnancy Category C
  2. Unknown Safety in Lactation
  • Resources
  1. Bumetanide Tablets (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=05cb961d-ac33-4bcf-b04e-411e496c43c1
  2. Bumetanide Intravenous Solution (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e71daa68-2744-47da-64b4-0a725c2e8457
  • References
  1. (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  4. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  5. Won Oh (2015) Electrolyte Blood Press 13(1):17-21 +PMID: 26240596 [PubMed]