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Prazosin

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Prazosin, Minipress

  • See Also
  1. Postsynaptic Alpha Adrenergic Antagonist
  • Indications
  1. Hypertension
    1. Not first-line antihypertensives, and avoid using as monotherapy (higher risk of CVA and CHF)
  • Efficacy
  1. Terazosin and Doxazosin are preferred over Prazosin (once daily dosing at similar cost)
  • Dosing
  1. Hypertension
    1. Start 1 mg orally twice daily to three times daily
    2. Titrate to usual daily total dose 20 mg divided two to three times daily
    3. Maximum total daily dose: 40 mg/day (but doses above 20 mg/day offer little additional benefit)
  • Safety
  1. Pregnancy Category C
  2. Unknown safety in Lactation
  • Mechanism
  1. See Alpha Adrenergic Receptor (Alpha-1 Antagonist)
  2. Peripheral Alpha-1 Adrenergic Antagonist
    1. Arterial and Venous Vasodilation
  • Adverse Effects
  1. See Postsynaptic Alpha Adrenergic Antagonist
  • Resources
  1. Prazosin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4db5fdc0-f5a2-49f0-8129-bad6e7c2f998
  • References
  1. (2020) Med Lett Drugs Ther 62(1598): 73-80
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia