-
Hypertension
- Not first-line Antihypertensives, and avoid using as monotherapy (higher risk of CVA and CHF)
-
Benign Prostatic Hypertrophy
- Selective Alpha-1a Antagonists (e.g. Tamsulosin) are preferred
-
Medical Expulsive Therapy for Ureteral Stone
- Replaced by the preferred Selective Alpha-1a Antagonists (e.g. Tamsulosin)
-
Hypertension
- Start 1 mg orally at bedtime
- Titrate to effective dose 1 to 5 mg daily or in divided doses
- Maximum 20 mg/day
-
Benign Prostatic Hypertrophy (replaced by Selective Alpha-1a Antagonists)
- Start 1 mg orally at bedtime
- Titrate to effect by doubling dose every 1-2 weeks (to 2, 5 and 10 mg)
- Observe for effects after 4 to 6 weeks on optimal dose (typically 10 mg)
- Maximum of 20 mg/day
- Pregnancy Category C
- Unknown safety in Lactation
- See Alpha Adrenergic Receptor (Alpha-1 Antagonist)
-
Peripheral Alpha-1 Adrenergic Antagonist
- Arterial and Venous Vasodilation
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia