Pharm

Tamsulosin

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Tamsulosin, Flomax

  • See Also
  1. Selective Alpha-1a Antagonist
  • Indications
  1. Benign Prostatic Hypertrophy
  2. Medical Expulsive Therapy for Ureteral Stone (Ureterolithiasis)
  • Dosing
  1. Start 0.4 mg orally daily
  2. Maximum 0.8 mg/day
  • Adverse Effects
  1. See Selective Alpha-1a Antagonist
  2. Rare Sulfa Allergy cross-reactivity
  3. Postural Hypotension (esp. when combined with Antihypertensives)
  4. Floppy Iris Syndrome
  5. Ejaculatory Dysfunction (class effect)
  • Drug Interactions
  1. Avoid all Selective Alpha-1a Antagonists with strong CYP3A4 inhibitors (e.g. Ketoconazole, Clarithromycin, Itraconazole, Ritonavir)
  2. Avoid Tamsulosin with strong CYP2D6 Inhibitors (e.g. Fluoxetine)
  • Resources
  1. Tamsulosin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bcd86877-5868-49dd-840b-7860b405fac7
  • References
  1. Hamilton (2020) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
  2. Nachawati (2022) Alpha Blockers, StatPearls, Treasure Island, FL, accessed 12/25/2022
    1. https://www.ncbi.nlm.nih.gov/books/NBK556066/