Pharm

Ritonavir

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Ritonavir, Norvir

  • See Also
  1. Anti-Retroviral Therapy
  2. Protease Inhibitor
  • Indications
  1. Used at low dose to "boost" most of the Protease Inhibitors
  • Mechanism
  1. Protease Inhibitor
  • Efficacy
  1. Very effective with Zidovudine (AZT) as well as other Protease Inhibitors
  • Adverse Effects (less common with the lower, "boosting dose")
  1. Gastrointestinal adverse effects may limit medication use
    1. Nausea or Vomiting
    2. Diarrhea
  2. Asthenia
  3. Paresthesias (Circumoral or peripheral)
  4. Triglycerides elevated
  5. Liver Function Tests
    1. Cholestatic enzymes elevated
    2. Hepatic transaminases elevated
  • Drug Interactions
  1. Rifampin
  2. Dexamethasone
  3. Anticonvulsants
  • Dosing
  1. Take with food
  2. Anticipate bad taste (Mix with chocolate milk)
  3. Full dose: 600 mg bid (not typically used at full dose due to adverse effects)
  4. Boosting dose varies from 100 mg daily up to 400 mg bid
  • References
  1. (1998) Med Lett Drugs Ther 40(1041):115 [PubMed]
  2. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
  3. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]