Pharm

Triamterene

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Triamterene, Dyrenium

  • See Also
  1. Amiloride
  2. Potassium-Sparing Diuretic
  • Indications
  1. Hypertension
    1. Weak Diuretic primarily used to counter urinary Potassium loss with other Diuretics
    2. Typically combined with Thiazide Diuretics (rarely used alone)
  • Contraindications
  1. Significant Renal Insufficiency
  2. Anuria
  3. Hyperkalemia
  • Mechanism
  1. Potassium-Sparing Diuretics only (Aldosterone independent)
  2. Primarily used to counter urinary Potassium loss with other Diuretics (e.g. Thiazide Diuretics)
  3. Act directly at the distal convoluted tubule (Aldosterone independent)
    1. Increase Sodium excretion
    2. Decrease Potassium secretion
  • Dosing
  1. Dose: 100 mg orally twice daily
  2. Maximum: 300 mg/day
  3. Typically used as Combination Medication with Thiazide Diuretic
    1. Diazide (37.5 to 50 mg Triamterene and 25 mg Hydrochlorothiazide)
    2. Maxide (75 mg Triamterene and 50 mg Hydrochlorothiazide)
  • Pharmacokinetics
  1. Rapidly absorbed, highly metabolized in liver and Kidney and rapidly excreted
  2. Onset: 2 to 4 hours
  3. Duration: 7 to 9 hours
  • Adverse Effects
  1. See Potassium-Sparing Diuretic
  2. Blue Urine Color
    1. Specific to Triamterene
  • Safety
  1. Pregnancy Category B
  2. Avoid in Lactation
  • Resources
  1. Triamterene (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fea50328-b3d5-4300-8c67-82cda0a975b7
  • References
  1. (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia