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Amiloride

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Amiloride, Midamor

  • See Also
  1. Triamterene
  2. Potassium-Sparing Diuretic
  • Indications
  1. Hypertension
    1. Weak Diuretics primarily used to counter urinary Potassium loss with other Diuretics
    2. Often combined with Thiazide Diuretics and rarely used alone
  • Contraindications
  1. Significant Renal Insufficiency
  2. Anuria
  3. Hyperkalemia
  • Mechanism
  1. Potassium-Sparing Diuretics only (Aldosterone independent)
  2. Primarily used to counter urinary Potassium loss with other Diuretics (e.g. Thiazide Diuretics)
  3. Act directly at the distal convoluted tubule (Aldosterone independent)
    1. Increase Sodium excretion
    2. Decrease Potassium secretion
  • Pharmacokinetics
  1. Renal excretion (unchanged in urine)
  2. Half-Life: 6 hours
  3. Onset: 2 hours
  4. Duration: 24 hours
  • Dosing
  1. Dose: 5 mg orally daily
  2. Maximum: 20 mg/day
  • Adverse Effects
  1. See Potassium-Sparing Diuretic
  • Safety
  1. Pregnancy Category B
  2. Unknown Safety in Lactation
  • Resources
  1. Amiloride (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e0cc2d44-436a-47e8-a890-589882fff4c4
  • References
  1. (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia