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Nadolol

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Nadolol, Corgard

  • See Also
  1. Beta Blocker
  • Indications
  1. Hypertension
  2. Migraine Prophylaxis
  3. Atrial Fibrillation Rate Control
  4. Angina
  5. Esophageal Varices Prevention of Recurrent Bleeding
  • Mechanism
  1. Nonselective Beta Blocker (Beta-1 and Beta-2 Adrenergic Blockade)
  • Dosing
  1. Dose: 40 mg orally daily
  2. Target: 40 to 80 mg/day
  3. Maximum 240 mg/day (Angina, Migraines, Atrial Fibrillation) to 320 mg/day (Hypertension)
  4. Renal Dysfunction
    1. Start 20 mg orally daily
    2. Decrease dosing frequency with Renal Insufficiency
      1. Creatinine Clearance 31 to 50 ml/min: Take every 24 to 36 hours
      2. Creatinine Clearance 10 to 30 ml/min: Take every 24 to 48 hours
      3. Creatinine Clearance <10 ml/min: Take every 40 to 60 hours
  • Adverse Effects
  1. See Beta Blocker
  • Metabolism
  1. Not lipophilic
  2. Renal excretion
  3. Long Half life
  • Safety
  1. Pregnancy Category C
  2. Avoid in Lactation
  • Resources
  1. Nadolol (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c899eedb-4113-45da-acc3-8e181250a7d8
  • References
  1. (2019) Presc Lett, Resource #350503, Comparison of Oral Beta Blockers
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia