Pharm

Ethacrynic Acid

search

Ethacrynic Acid, Edecrin

  • See Also
  1. Loop Diuretic
  • Indications
  1. See Loop Diuretic
  2. Ethacrynic Acid is the only Loop Diuretic that is not a Sulfonamide
  • Mechanism
  1. See Loop Diuretic
  • Dosing
  • Adult
  1. Oral
    1. Start: 25 mg orally daily
    2. Increase to 50 mg orally twice daily after first day
    3. Increase to 100 mg orally in the AM and 50 to 100 mg orally in PM
    4. Maximum: 200-400 mg divided twice daily
    5. Onset: 30 minutes
    6. Duration: 6 to 8 hours
  2. Intravenous
    1. Infusion concentration: 50 mg/ml
    2. Start: 0.5 to 1 mg/kg IV slowly over 20 to 30 minutes
    3. Maximum: 100 mg/dose
    4. IV Dose in 2023 costs $2500 in U.S.
    5. Onset: 5 minutes
    6. Duration: 2 hours
  • Dosing
  • Child
  1. Not FDA approved for use in children, and avoid in infants
  2. IV: 1 mg/kg IV
  • Adverse Effects
  1. See Loop Diuretic
  2. Ototoxicity
    1. Most potentially ototoxic of the Loop Diuretics
  • Safety
  1. Pregnancy Category B
  2. Unknown Safety in Lactation
  • Drug Interactions
  1. Increases Lithium levels
  • Resources
  1. Ethacrynic Acid Tablet (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b9bc3907-bfa7-4d9f-90d9-c2097230f7e4
  2. Ethacrynic Acid Intravenous Solution (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=db836794-dc0f-4109-9c27-6aaf391b3389
  • References
  1. (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia