Pharm

Timolol

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Timolol, Blocadren

  • See Also
  1. Beta Blocker
  2. Intraocular Timolol
  • Indications
  1. Hypertension
  2. Migraine Prophylaxis
  3. Post-Myocardial Infarction
  • Mechanism
  1. Nonselective Beta Blocker (Beta-1 and Beta-2 Adrenergic Blockade)
  • Dosing
  1. Start 10 mg orally twice daily
  2. Target 20-40 mg/day divided twice daily
  3. Maximum 60 mg/day
  • Pharmacokintics
  1. Mildly lipophilic
  2. Moderate first pass liver metabolism
  3. Hepatic elimination
  4. CYP2D6 metabolism
  • Adverse Effects
  1. See Beta Blocker
  • Safety
  1. Pregnancy Category C
  2. Safe in Lactation
  • Resources
  1. Timolol (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=57c62928-63d8-4505-9b9e-c085a3a12c95
  • References
  1. (2019) Presc Lett, Resource #350503, Comparison of Oral Beta Blockers
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia