Pharm

Gemfibrozil

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Gemfibrozil, Lopid

  • See Also
  1. Fibric Acid Derivative
  2. Hyperlipidemia
  3. Hypertriglyceridemia
  4. Gemfibrozil
  5. Fenofibrate
  6. Fenofibric Acid
  • Indications
  1. See Fibric Acid Derivative
  2. Hypertriglyceridemia
  • Contraindications
  1. See Fibric Acid Derivative
  2. Avoid in Serum Creatinine >=2 mg/dl
  • Dosing
  1. Take 600 mg orally twice daily at 30 minutes before meals
  • Efficacy
  1. See Fibric Acid Derivative
  2. No Fibrate has been shown to reduce all cause mortality
  3. Gemfibrozil is the only Fibrate shown to decrease cardiovascular events
    1. NNT to prevent one coronary event: 46-125
  • Adverse Effects
  1. See Fibric Acid Derivative
  • Safety
  1. Pregnancy Category C
  2. Unknown safety in Lactation
  • Drug Interactions
  1. See Fibric Acid Derivative
  2. Avoid with specific other medications
    1. Statins (esp. Simvastatin)
    2. Dasabuvir
    3. Repaglinide
  3. Increases levels of other medications
    1. CYP2C8 Substrates (e.g. Montelukast, Paclitaxel, Pioglitazone)
    2. OATP1B1 Substrates (e.g. Ezetimibe, Glyburide, Olmesartan, Rifampin)
    3. Warfarin
  • Resources
  1. Gemfibrozil (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4e9e08da-9700-4934-a2b1-4f64c70ea8a2
  • References
  1. Last (2011) Am Fam Physician 84(5): 551-8 [PubMed]
  2. Studer (2005) Arch Intern Med 165(7): 725-30 [PubMed]
  3. Sharma (2009) Ann Intern Med 151(9):622-30 [PubMed]