Pharm

Olmesartan

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Olmesartan, Benicar, Olmetec, Azor, Benicar HCT

  • See Also
  1. Angiotensin Receptor Blocker
  • Indications
  1. See Angiotensin Receptor Blocker
  2. Hypertension
  • Contraindications
  1. See Angiotensin Receptor Blocker
  • Mechanism
  1. See Angiotensin Receptor Blocker
  • Dosing
  • Adults
  1. Hypertension
    1. Start 20 mg orally daily
    2. Maximum 40 mg/day
  • Dosing
  • Children (age 6 to 16 years)
  1. Hypertension
    1. Weight 20 to 35 kg (and age >=6 years old)
      1. Start 10 mg orally daily
      2. Maximum 20 mg orally daily
    2. Weight >=35 kg (and age 6 to 16 years old)
      1. Use adult dosing (see above)
  • Medications
  • Combinations
  1. Amlodipine and Olmesartan (Azor)
  2. Hydrochlorothiazide and olemesartan (Benicar HCT)
  • Adverse Effects
  1. See Angiotensin Receptor Blocker
  2. Sprue-like Enteropathy
    1. Appears specific to Olmesartan (not ARB class effect)
    2. Presents with progressive, severe Chronic Diarrhea, weight loss and sprue-like intestinal changes
    3. May be a delayed Hypersensitivity Reaction (typically months to years after starting Olmesartan)
    4. Rubio-Tapia (2012) Mayo Clin Proc 87(8):732-8 [PubMed]
  • Safety
  1. See Angiotensin Receptor Blocker
  2. Pregnancy Category X
  3. Unknown Safety in Lactation
  • Resources
  1. Olmesartan (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e5dbca00-4e1b-4479-b829-021b11bc021e
  • References
  1. (2018) Presc Lett, Resource #340901, Angiotensin Receptor Blocker (ARB) Antihypertensive Dose Comparison
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia