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Colestipol

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Colestipol, Colestid

  • See Also
  1. Bile Acid Sequestrant
  2. Hyperlipidemia
  3. Hyperlipidemia Management
  4. Cholestyramine
  5. Colesevelam
  • Indications
  1. Hyperlipidemia adjunctive management (rare use)
  • Contraindications
  1. See Bile Acid Sequestrant
  2. Serum Triglycerides >400 mg/dl
  • Mechanism
  1. See Bile Acid Sequestrant
  2. Binds bile salts
    1. Results in insoluble complexes that are excreted in the stool
  • Dosing
  • Adult
  1. Tablets (1 gram each)
    1. Start 2 grams orally twice daily with a 6 to 8 ounces of liquid
    2. Maximum: 16 grams/day
  2. Granules (5 grams per 7.5 grams powder)
    1. Start 5 grams orally twice daily in 90 ml non-carbonated liquid
    2. Titrate in 5 gram increments every 1 to 2 months
    3. Maximum: 30 g/day
  • Dosing
  • Child
  1. Not FDA approved in children
  2. Start 125 to 250 mg/kg/day orally divided 2 to 4 times daily up to 10 to 20 grams/day
  • Drug Interactions
  1. See Bile Acid Sequestrant
  2. Take other medications at least 1 hour before 4 to 6 hours after Colestipol
  3. Take with water or orange juice before meals
  • Efficacy
  1. See Bile Acid Sequestrant
  • Adverse Effects
  1. See Bile Acid Sequestrant
  2. Constipation
  • Safety
  1. Pregnancy Category B
  2. Considered Safe in Lactation
  • Metabolism
  1. Not absorbed
  • Resources
  1. Colestipol (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fa6c3e11-84e9-433d-aa74-7cd34336bbed
  • References
  1. (2022) Non-StatinLipid Lowering Agents, Presc Lett, Resource #380202
  2. (2022) Med Lett Drugs Ther 64(1659): 145-52
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  4. (2000) Med Lett Drugs Ther 42:102-4 [PubMed]