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Sodium Channel Blocker

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Sodium Channel Blocker

  • See Also
  1. Sodium Channel Blockade Antiarrhythmic
  • Causes
  • Cardiovascular
  1. Antiarrhythmics
    1. See Sodium Channel Blockade Antiarrhythmics
    2. Class Ia: Lengthens Action Potential duration
      1. Quinidine
      2. Procainamide (Pronestyl)
      3. Disopyramide (Norpace)
      4. Amiodarone (also Class II, III, IV)
      5. Ajmaline (used to diagnostically provoke Arrhythmia in suspected Brugada Syndrome)
    3. Class Ib: Shortens Action Potential duration
      1. Lidocaine (Xylocaine)
      2. Tocainide (Tonocard)
      3. Mexiletine (Mexitil)
      4. Aprindine
    4. Class Ic: Slows conduction
      1. Flecainide (Tambocor)
      2. Encainide (Enkaid)
      3. Propafenone (Rythmol)
      4. Moracizine (Ethmozine, off U.S. market in 2007)
  2. Diuretic
    1. Triamterene
    2. Amiloride
  3. Beta-Blockers (esp. non-selective)
    1. Acebutolol
    2. Oxprenolol
    3. Propranolol
  • Causes
  • Neurologic
  1. Seizure
    1. Lamotrigine
    2. Oxcarbazepine
    3. Phenytoin (Dilantin, Shortens Action Potential duration)
    4. Fosphenytoin
    5. Eslicarbazepine
    6. Carbamazepine
    7. Lacosamide
    8. Topiramate
    9. Rufinamide
  2. Anesthetic
    1. Lidocaine
  3. Muscle Relaxants
    1. Cyclobenzaprine
  • Causes
  • Psychiatric
  1. Tricyclic Antidepressant
    1. Amitriptyline
    2. Desipramine
    3. Imipramine
    4. Nortriptyline
  2. Other Antidepressants (SSRI, SNRI)
    1. Bupropion
    2. Citalopram
    3. Fluoxetine
    4. Paroxetine
    5. Venlafaxine
  3. Antipsychotics
    1. Thioridazine
    2. Loxapine
  • Causes
  • Miscellaneous
  1. Amantadine
  2. Cocaine
  3. Tetrodotoxin
  4. Tramadol
  5. Antihistamines
    1. Chlorpheniramine
    2. Diphenhydramine
    3. Dimenhydrinate
    4. Doxepin
  6. Antimalarial Agents
    1. Chloroquine
    2. Hydroxychloroquine
    3. Quinine
  • Resources
  1. Sodium Channel Blocker Toxicity (Internet Book of Critical Care)
    1. https://emcrit.org/ibcc/nacb/