Pharm
Chlorpheniramine
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Chlorpheniramine
, Chlor-Trimeton, Aller-Chlor
See Also
Antihistamine
Anticholinergic Toxicity
Indications
Allergic Rhinitis
Mechanism
See
Antihistamine
H1 Receptor
Antagonist
Chlorpheniramine is an alkylamine
First Generation Antihistamine
with moderate
Anticholinergic
activity
Precautions
Although FDA approved for children, FDA does not recommend routine
Antihistamine
use age <4 years
Deaths have occurred in younger children related to
Anticholinergic Toxicity
Dosing
Regular Release Formulation
Adult (age >=12 years): 4 mg orally every 4 to 6 hours
Child (age 6 to 11 years): 2 mg orally every 4 to 6 hours
Child (age 2 to 5 years): 1 mg orally every 4 to 6 hours (NOT fda approved)
Dosing
Timed Release Formulation
Adult (age >=12 years): 8 mg orally every 8 hours OR 12 mg orally every 12 hours
Child (age 6 to 11 years): 8 mg orally every 12 hours (NOT fda approved)
Adverse Effects
See
Antihistamine
See
Anticholinergic Toxicity
Sedation
Safety
Pregnancy category B
Avoid in
Lactation
Resources
Chlorpheniramine (DailyMed)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0aa4ac07-bd02-46b2-9cf0-0643e0e1a2da
References
Olson (2020) Clinical
Pharmacology
, Medmaster Miami, p. 146-7
Hamilton (2020) Tarascon Pocket Pharmacopoeia
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