Diffuse

Connective Tissue Disorder

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Connective Tissue Disorder, Connective Tissue Disease

  • Findings
  1. Synovitis (hallmark finding in Connective Tissue Disorders)
  • Labs
  • Screening Indications
  1. Precautions
    1. Connective Tissue Disorder labs are nonspecific
    2. Obtain labs only if a reasonable suspicion for underlying condition
  2. Antinuclear Antibody test
    1. Mixed Connective Tissue Disease
      1. Confirm with anticardiolipin ab, anti-CCP, Anti-Jo1, Anti-RNP, Anti-Scl-70, Rheumatoid Factor
    2. Dermatomyositis or Polymyositis
      1. Confirm with Myositis-specific antibodies (e.g. Anti-Jo1)
    3. Sjogren Syndrome
      1. Confirm with Sjogren antibodies (Anti-SSA, Anti-SSB)
    4. Systemic Lupus Erythematosus
      1. Confirm with anticardiolipin ab, Anti-dsDNA, Anti-SSA, Anti-SSB, Anti-Sm, Anti-U1 snRNP, Lupus Anticoagulant
  3. Antineutrophil Cytoplasmic Antibody (ANCA)
    1. Vasculitis
      1. Confirm with antiproteinase 3 Antibody, antimyeloperoxidase Antibody
  4. Rheumatoid Factor
    1. Rheumatoid Arthritis
      1. Confirm with Anticyclic Citrullinated Peptide Antibody (anti-CCP)
  5. Creatinine Phosphokinase (CPK)
    1. Dermatomyositis or Polymyositis
      1. Confirm with Myositis-specific antibodies (e.g. Anti-Jo1)