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Anti-Topoisomerase I Antibody

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Anti-Topoisomerase I Antibody, Anti-Topoisomerase1 Antibody, Anti-Scl-70 Antibody, Anti-Topoisomerase I, Topoisomerase 1 Antibody, Anti-DNA-Topoisomerase I, Anti-Scl-70

  • See Also
  1. Antinuclear Antibody
  • Causes
  • Negative
  1. Normal
  • Causes
  • Positive (Percentage refers to sensitivity)
  1. Scleroderma (20-30% sensitivity)
    1. Anti-Scl-70 is highly specific for Scleroderma
    2. Implies a poor prognosis
  2. Associated with renal involvement
  • References
  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
  4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]