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Anticyclic Citrullinated Peptide Antibody

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Anticyclic Citrullinated Peptide Antibody, Anti-cyclic Citrullinated Peptide Antibody, Anti-Citrullinated Protein Antibody

  • See Also
  1. Rheumatoid Arthritis
  2. Rheumatoid Factor
  • Indications
  1. Rheumatoid Arthritis Diagnosis confirmation
    1. Rheumatoid Factor or Antinuclear Antibody positive
    2. May also predict prognosis and erosive disease likelihood
    3. Does not correlate to therapy response (not used for monitoring)
  • Mechanism
  1. Enzyme-linked Immunosorbent Assay (ELISA)
  1. Test Sensitivity: 67%
  2. Test Specificity: 95%
  3. Positive Likelihood Ratio (LR+): 12.46
  4. Negative Likelihood Ratio (LR-): 0.36
  • References
  1. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]
  2. Barra (2011) Rheumatology 50(2): 311-6 [PubMed]
  3. Nishimura (2007) Ann Intern Med 146(11): &97-808 [PubMed]