Diffuse

Mixed Connective Tissue Disease

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Mixed Connective Tissue Disease, Sharp Syndrome, MCTD Syndrome

  • Definitions
  1. Mixed Connective Tissue Disease (MCTD)
    1. Condition with combined features of Systemic Lupus Erythematosus, Myositis and Scleroderma
  • Findings
  • Presentation
  1. Raynaud Phenomenon
  2. Pulmonary Hypertension
  3. Arthritis
  4. Myositis
  • Labs
  1. Screening
    1. ANA Titer
  2. Confirmation
    1. Anti-ribonucleoprotein Antibody (Anti-RNP)
      1. Test Sensitivity for MCTD: 71-100%
      2. Test Specificity for MCTD: 84-100%
  • References
  1. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]