- Hypersensitivity Reaction (associated with Eosinophilia, rash)
- Idiosyncratic Reaction
- Drug-Induced Hyperthemia Syndromes (Muscle rigidity and fever >40 C)
- Intensive Care Unit Patients
- Rigors (53%)
- Myalgias (25%)
- Leukocytosis (22%)
- Eosinophilia (22%)
- Rash (18%)
- Hypotension (18%)
- Antimicrobial Induced Fever
- Amphotericin
- Carbapenems
- Cephalosporins (common)
- Erythromycin
- Isoniazid
- Minocycline
- Penicillins (common)
- Nitrofurantoin
- Rifampin
- Sulfonamides
- Vancomycin
- Cardiovascular Medication Induced Fever
- Anticonvulsant induced fever
- Barbiturates
- Carbamazepine (Tegretol)
- Phenytoin or Dilantin (common)
- Gastrointestinal Medication induced fever
- Cimetidine (Tagemet)
- Ranitidine (Zantac)
- Phenothiazines
- Miscellaneous Medications Inducing Fever
- Withdraw suspected medication causes
- Expect fever to resolve within 2-3 days (up to 7 days) of medication discontinuation
- Exclude other sources of fever
- Marino (2014) The ICU Book, p. 777-95
- Hersch (2014) Am Fam Physician 90(2): 91-6 [PubMed]
- Johnson (1996) Infect Dis Clin North Am 10(1): 85-91 [PubMed]