Analgesic

Ibuprofen

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Ibuprofen, Motrin, Advil, Nuprin

  • Indications
  1. Fever
  2. Analgesia
  • Mechanism
  • NSAID - Propionic Acid
  1. Strong Analgesic action
  2. Moderate anti-inflammatory action (Dose >= 600 mg)
  • Supplied
  1. Suspension: 100 mg/5ml
  2. Chewables: 50 mg, 100 mg
  3. Oral drops: 40 mg/ml
  4. Tablets: 100 mg, 200 mg, 300 mg, 400 mg, 600 mg, 800 mg
  • Dosing
  • Children older than age 6 months
  1. Dose: 5-10 mg/kg PO every 6 to 8 hours
  • Dosing
  • Adult
  1. Dose: 400 to 800 mg orally three to four times daily
  2. Maximum: 3200 mg/day
  3. Ibuprofen Analgesic ceiling is 400 mg
    1. Doses 600 mg and 800 mg offer little additional Analgesic benefit above the 400 mg dose
    2. Motov (2019) Ann Emerg Med 74(4): 530-7 +PMID:31383385 [PubMed]
  • Contraindications
  1. Avoid in age under 6 months old
  • Adverse Effects
  1. See NSAID Gastrointestinal Adverse Effects
  2. See NSAID Renal Adverse Effects