Analgesic
Ibuprofen
search
Ibuprofen
, Motrin, Advil, Nuprin, NeoProfen, Caldolor, Rufen, Duexis
See Also
Nonsteroidal Anti-inflammatory
Indications
See
NSAID
FDA approved indications in Adults
Rheumatoid Arthritis
Osteoarthritis
Acute
Gouty Arthritis
Mild to moderate pain
Primary Dysmenorrhea
Migraine Headache
Fever
FDA approved indications in Children (age >6 months except in PDA)
Juvenile Rheumatoid Arthritis
Mild to moderate pain
Fever
Patent Ductus Arteriosus
(PDA) in premature newborns (NeoProfen)
Contraindications
See
NSAID
Avoid in age under 6 months old
Mechanism
NSAID
in Propionic Acid class
Strong
Analgesic
action
Moderate anti-inflammatory action (Dose >= 600 mg)
Medications
Ibuprofen
Suspension: 100 mg/5ml
Chewables: 50 mg, 100 mg
Oral drops: 40 mg/ml
Tablets: 100 mg, 200 mg, 300 mg, 400 mg, 600 mg, 800 mg
Intravenous (Caldolor)
Adults: 400 to 800 mg IV infused over 30 minutes every 6 hours as needed
Combinations
Duexis (Ibuprofen 800 mg and
Famotidine
26.6 mg)
Take one tablet orally up to three times daily (swallowed whole and not cut)
FDA approved for
Osteoarthritis
and
Rheumatoid Arthritis
Dosing
Children older than age 6 months
Dose: 5-10 mg/kg orally every 6 to 8 hours
Maximum: 40 mg/kg/day up to 2400 mg/day
See other references for NeoProfen in
Patent Ductus Arteriosus
(PDA)
Dosing
Adult
See Caldolor IV dosing above
Dose: 400 to 800 mg orally three to four times daily
See efficacy below regarding
Analgesic
ceiling dose of 400 mg
Arthritis
(RA,OA, gout) dose: 600 to 800 mg orally every 6 to 8 hours as needed
Analgesic
and antipyretic dose: 200 to 400 mg orally every 4 to 6 hours as needed
Maximum: 3200 mg/day
Adverse Effects
See
NSAID Gastrointestinal Adverse Effects
See
NSAID Renal Adverse Effects
Safety
See
NSAID
Considered safe in
Lactation
Avoid
NSAID
s in pregnancy outside the first part of the second trimester (13 to 20 weeks)
Teratogen
ic in first trimester
Risk of premature ductus arteriosus closure in the fetus in third trimester
Most
NSAID
s carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
However, many obstetricians avoid
NSAID
s entirely in pregnancy (even in second trimester)
Drug Interactions
Aspirin
Ibuprofen counters
Aspirin
antiplatelet effects
Take
Aspirin
at least 2 hours before Ibuprofen dose
Efficacy
Ibuprofen
Analgesic
ceiling is 400 mg
Doses 600 mg and 800 mg offer little additional
Analgesic
benefit above the 400 mg dose
Motov (2019) Ann Emerg Med 74(4): 530-7 +PMID:31383385 [PubMed]
Resources
Ibuprofen (DailyMed)
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8ea0e303-3967-4d71-8255-ac42a841ce28
Ibuprofen (StatPearls)
https://www.ncbi.nlm.nih.gov/books/NBK542299/
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