- Serotonin Syndrome
- Neuroleptic Malignant Sydnrome
- Rare, inhalational Anesthetic related rapid rise in Body Temperature, Muscle rigidity, Hypertension and Tachypnea
- Rare general Anesthesia complication
- Autosomal Dominant inherited defect
- Similar to Neuroleptic Malignant Syndrome (due to Antipsychotics)
-
Anesthetic agents in combination with genetic predisposition
- Inhalational Anesthetics
- Succinylcholine
- Hyperthermia
- Muscle Rigidity
- Hypertension
- Tachypnea
- Abnormalities
- Metabolic Acidosis
- Respiratory Acidosis
- Creatinine Phosphokinase (CPK) increased (Rhabdomyolysis)
- Serum Creatinine increased
- Disseminated Intravascular Coagulation (DIC)
- Respiratory Failure
- Renal Failure
- Cardiovascular Collapse
- Rhabdomyolysis
-
Dantrolene (specific treatment of choice)
- Adult: 1 to 3 mg/kg IV
- Child: 0.5 to 1 mg/kg IV
- Supportive measures (especially until Dantrolene available)
- Benzodiazepines
- Cooling
- (2016) CALS, 14th Ed, 1:126