Pharm

Indinavir

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Indinavir, Crixivan

  • See Also
  1. Anti-Retroviral Therapy
  2. Protease Inhibitor
  • Mechanism
  1. Protease Inhibitor
  • Efficacy
  1. Very effective in combination with Zidovudine (AZT)
  • Dosing
  1. Indinavir 600 mg PO tid ($360/month)
  2. Take on empty Stomach
    1. One hour before or 2 hours after a meal
    2. Concurrent food reduces concentration up to 80%
  3. Drink at least 1.5 Liters (50 oz) liquid per day
    1. Drink 150 ml water per hour for 3 hours after dose
    2. Avoids Nephrolithiasis and Interstitial Nephritis
  • Adverse Effects
  1. See Protease Inhibitor for adverse effects attributed to the class
  2. Well tolerated
  3. Indirect Bilirubin elevation in 10% of patients
  4. Nephrolithiasis in 2-3% of patients
  5. Renal Insufficiency
  6. Alopecia
  7. Dry Skin
  8. Xerostomia
  9. Paronychia
  10. Gallstones
  • Drug Interactions
  1. St. John's Wort
    1. May reduce Indinavir concentrations by 80%
    2. Piscitelli (2000) Lancet 355:547-8 [PubMed]
  • References
  1. (1998) Med Lett Drugs Ther 40(1041):115 [PubMed]
  2. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
  3. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]