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Alfuzosin

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Alfuzosin, Uroxatral

  • See Also
  1. Selective Alpha-1a Antagonist
  • Indications
  1. Benign Prostatic Hypertrophy
  2. Medical Expulsive Therapy for Ureteral Stone (Ureterolithiasis)
  • Contraindications
  1. Contraindicated in moderate to severe liver disease (and Exercise caution in renal disease)
  • Dosing
  1. Take 10 mg once daily
  • Adverse Effects
  1. See Selective Alpha-1a Antagonist
  2. Postural Hypotension (esp. when combined with Antihypertensives)
  3. Floppy Iris Syndrome
  4. Ejaculatory Dysfunction (class effect)
    1. Alfuzosin ER is least likely to cause ejaculatory dysfunction of the selective alpha agents
  • Drug Interactions
  1. Avoid all Selective Alpha-1a Antagonists with strong CYP3A4 inhibitors (e.g. Ketoconazole, Clarithromycin, Itraconazole, Ritonavir)
  • Resources
  1. Alfuzosin Extended Release (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f075a897-7bef-4799-b7e2-7e051c461443
  • References
  1. Hamilton (2020) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
  2. Nachawati (2022) Alpha Blockers, StatPearls, Treasure Island, FL, accessed 12/25/2022
    1. https://www.ncbi.nlm.nih.gov/books/NBK556066/