Pharm

Triazolam

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Triazolam, Halcion

  • See Also
  1. Benzodiazepine
  • Indications
  1. Insomnia
    1. Short-term use only
  • Class
  1. Short Acting Benzodiazepine
  • Dose
  1. Adult: 0.125 to 0.25 mg orally at bedtime for 7 to 10 days as needed
  2. Elderly: 0.125 mg orally at bedtime for 7 to 10 days as needed
  3. Maximum: 0.5 mg at bedtime (0.25 mg is sufficient in most patients)
  • Pharmacokinetics
  1. Half-Life: 1.5-5.5 hours
  2. Metabolized by CYP3A4 to inactive metabolites
  • Precautions
  1. Reports of Psychosis and Violence
    1. Associated with high dose Halcion (>1 mg)
  2. Likely to be as safe as other Benzodiazepines
  • Safety
  1. Pregnancy Category X
  2. Avoid in Lactation
  3. Schedule IV Controlled Substance
  • Resources
  1. Triazolam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5add318e-11b9-42f8-b052-0d8cebb32fcf
  • References
  1. (2019) Med Lett Drugs Ther 61(1578): 121-6
  2. (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia