Pharm
Alkylating Agent
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Alkylating Agent
Mechanism
Exert cytotoxic effects via transfer of alkyl group
DNA alkylation (key to cellular lethality)
Chemically react with many cellular constituents
DNA cross linking is a primary role of agents
Replicating cells are most susceptible to agents
Alkylating Agents are not cell cycle specific
Types
Bis (chloroethyl) amines
Cyclophosphamide
Mechlorethamine
Chlorambucil
Melphalan
Nitrosoureas
Carmustine (BCNU)
Lomustine (CCNU)
Semustine (Methyl-CCNU)
Aziridines
Thiotepa
Triethylenemelamine
Alkylsulfonates
Busulfan
Other drugs causing alkylation
Procarbazine
Dacarbazine
Hexamethylmelamine
Cisplatin
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