Pharm

Chlorambucil

search

Chlorambucil, Leukeran

  • See Also
  1. Chemotherapy
  2. Alkylating Agent
  • Indications
  1. FDA-Approved
    1. Chronic Lymphocytic Leukemia (CLL)
    2. Lymphoma
  2. Off-Label
    1. Behcet's Disease (Meningoencephalitis, Uveitis)
    2. Membranous Nephropathy
    3. Ovarian Cancer
  • Mechanism
  1. See Alkylating Agent
  2. Antineoplastic aromatic nitrogen mustard
    1. As with other Alkylating Agents (and nitrogen mustards), cross-links DNA
  • Medications
  1. Chlorambucil Tablets (Leukeran): 2 mg
  • Dosing
  1. See other references for disease specific dosing protocols
  • Adverse Effects
  1. Alopecia
  2. Bone Marrow Suppression
  3. Impaired future fertility
  4. Secondary Malignancy
  5. Seizures
  • Safety
  1. Avoid in Lactation
  2. Pregnancy Category D (avoid)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count
  • Drug Interactions
  1. Live Vaccines
    1. Avoid while on Chlorambucil
  • Resources
  1. Chlorambucil Tablet (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e3d7a0f9-d704-4676-b16e-622ff6d22aa2