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Dacarbazine

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Dacarbazine

  • See Also
  1. Temozolomide
  2. Chemotherapy
  3. Alkylating Agent
  • Indications
  1. FDA Approved
    1. Hodgkin Lymphoma
    2. Melanoma (metastatic)
  2. Off-Label
    1. Medullary Thyroid Cancer
    2. Panceatic Neuroendocrine Masses
    3. Pheochromocytoma (malignant)
    4. Soft Tissue Sarcoma
  • Mechanism
  1. See Alkylating Agent
  2. Triazene derived antineoplastic
    1. Prodrug that is metabolized in the liver to the active MTIC (monomethyl triazeno imidazole carboxamide)
    2. Similar to Temozolomide, which is metabolized to MTIC at physiologic pH
  3. Acts as an DNA Alkylating Agent, cross-linking DNA and blocking cell function and replication
  • Dosing
  1. See other references for disease specific dosing protocols
  • Adverse Effects
  1. Alopecia
  2. Bone Marrow Suppression
  3. Gastrointestinal (Nausea, Vomiting, Anorexia)
  4. Hepatotoxicity
  5. Secondary Malignancy
  6. Soft Tissue Injury on extravasation
    1. May result in severe local tissue necrosis
  • Safety
  1. Avoid in Lactation
  2. Avoid in Pregnancy (all trimesters)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests
  • Resources
  1. Dacarbazine Powder for Injection Solution (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=26e91082-7698-4680-beab-07c47802f0f9
  2. Dacarbazine (LiverTox)
    1. https://www.ncbi.nlm.nih.gov/books/NBK548913/