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Mechlorethamine

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Mechlorethamine, Valchlor

  • See Also
  1. Chemotherapy
  2. Alkylating Agent
  • Indications
  1. Cutaneous T Cell Lymphoma (Stage 1A and 1B)
  • Mechanism
  1. See Alkylating Agent
  2. Synthetic, nitrogen mustard Alkylating Agents used as a topical antineoplastic
  3. As with other Alkylating Agents, cross-binds DNA, blocking cell replication and other cellular functions
  • Medications
  1. Topical Mechlorethamine (Valchlor): 0.016% Topical Gel
  • Dosing
  1. See other references for disease specific dosing protocols
  • Adverse Effects
  1. Dermatitis
  2. Secondary Malignancy (non-melanoma Skin Cancer)
  • Safety
  1. Avoid in Lactation
  2. Avoid in Pregnancy (all trimesters)
    1. Use reliable Contraception
  • Resources
  1. Mechlorethamine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6a52e4c2-6a9f-4ebb-bc77-046b4f8bcd57