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Mammalian Target of Rapamycin Inhibitor

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Mammalian Target of Rapamycin Inhibitor, mTOR Inhibitor, Sirolimus, Everolimus

  • Indications
  1. Solid Organ Transplant Immunosuppression (maintenance prevention of rejection)
  • Preparations
  1. Sirolimus
  2. Everolimus
  • Adverse Effects
  1. Hyperlipidemia
  2. Hepatic artery thrombosis
  3. Myelosuppression
  4. Pulmonary fibrosis
  5. Rash
  6. Delayed Wound Healing
  • Drug Interactions
  1. See Cytochrome P-450 3A4
  2. Agents that increase Purine Synthesis Inhibitor concentrations
    1. Linezolid potentiates myelosuppression
    2. Erythromycin (and Clarithromycin to a lesser extent)
  3. Agents that decrease Purine Synthesis Inhibitor concentrations
    1. Rifampin
  • References
  1. Cimino (2016) Am Fam Physician 93(3): 203-10 [PubMed]
  2. Costanzo (2010) J Heart Lung Transplant 29(8): 914-56 [PubMed]