Pharm
Purine Synthesis Inhibitor
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Purine Synthesis Inhibitor
, Mycophenolate, Cellcept, Mycophenolic acid, MyFortic
See Also
Azathioprine
(
Imuran
)
Indications
Solid Organ Transplant
Immunosuppression
(maintenance prevention of rejection)
Adverse Effects
Mycophenolate or Mycophenolic acid
See
Azathioprine
(
Imuran
)
Bone Marrow
suppression
Gastrointestinal adverse effects (e.g.
Nausea
,
Vomiting
,
Diarrhea
,
Abdominal Pain
)
Preparations
Azathioprine
(
Imuran
)
Mycophenolate (Cellcept)
Mycophenolic acid (MyFortic)
Drug Interactions
See
Cytochrome P-450 3A4
Agents that increase Purine Synthesis Inhibitor concentrations
Linezolid
Valganciclovir
(
Valcyte
) potentiates myelosuppression
Allopurinol
(esp.
Azathioprine
)
Agents that decrease Purine Synthesis Inhibitor concentrations
Rifampin
References
Cimino (2016) Am Fam Physician 93(3): 203-10 [PubMed]
Costanzo (2010) J Heart Lung Transplant 29(8): 914-56 [PubMed]
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