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Nucleotide antimetabolite with antineoplastic activity
- Fludarabine is a fluorinated analog of vidarabine (ara-A), an Antiviral Agent
- Fludarabine is a prodrug, infused as a phosphate salt (Fludarabine phosphate)
- Dephosphorylated to 2-fluoro-ara-A (rapidly on intravenous infusion)
- Intracellularly phosphorylated to the active triphosphate, 2-fluoro-ara-ATP (via deoxycytidine kinase)
- 2-fluoro-ara-ATP inhibits DNA Polymerase, ribonucleotide reductase and DNA primase
- Inhibits tumor cell growth
- Fludarabine IV Solution in 50 mg vials
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Monitoring
- Complete Blood Count
- Renal Function tests
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