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Nelarabine

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Nelarabine, Arranon

  • See Also
  1. Chemotherapy
  2. Antimetabolite Chemotherapy
  • Indications
  1. T Cell Acute Lymphoblastic Leukemia or Lymphoma (relapse or refractory)
  • Mechanism
  1. Purine Antimetabolite (arabinonucleoside) with antineoplastic activity
  2. Nelarabine is demethoxylated by Adenosine deaminase to its biologically active metabolite, Ara-G
    1. Ara-G (9-beta-D-arabinosylguanine) incorporates into DNA
    2. Inhibits DNA synthesis
  • Medications
  1. Nelarabine IV Solution: 5 mg/ml in 50 ml vials
  • Dosing
  1. See other references for disease specific dosing protocols
  • Adverse Effects
  1. Myelosuppression
  2. Neurotoxicity
    1. Altered Mental Status
    2. Demyelination (rare)
    3. Headache
    4. Paralysis
    5. Peripheral Neuropathy
    6. Seizures
    7. Somnolence
  • Safety
  1. Avoid in Pregnancy (any trimester)
    1. Use reliable Contraception
  2. Avoid in Lactation
  3. Monitoring
    1. Renal Function Tests
  • Resources
  1. Nelarabine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fffa5d75-0dba-4ad7-a252-5f60fa28489a