Pharm
Cladribine
search
Cladribine
, Leustatin, Chlorodeoxyadenosine, 2-CDA
See Also
Chemotherapy
Antimetabolite Chemotherapy
Indications
FDA Approved
Hairy Cell Leukemia
Off-Label Use
Acute Myelogenous Leukemia
(adults and children)
Advanced Cutaneous T Cell
Lymphoma
Autoimmune Hemolytic Anemia
Chronic Lymphocytic Leukemia
(CLL)
Langerhans Cell Histiocytosis
(children)
Multiple Sclerosis
(progressive)
Non-Hodgkin Lymphoma
Sezary Syndrome
Waldenstrom's Macroglobulinemia
Mechanism
Purine
Nucleoside
antimetabolite analog
Cladribine is metabolized intracellularly to 2-CdATP (Cladribine triphosphate, an active metabolite)
2-CdATP incorporates into DNA
Results in DNA single strand breaks
Also depletes energy molecules
Nicotinamide Adenine Dinucleotide
(NAD)
Adenosine Triphosphate
(ATP)
Selectively more toxic to cancerous
Lymphocyte
s and
Monocyte
s
Cladribine is resistant to
Adenosine
deaminase (therefore selective for
Lymphocyte
s and
Monocyte
s)
Noncancerous
Lymphocyte
s and
Monocyte
s are less responsive to Cladribine
Medications
IV Solution: 10 mg per 10 ml vials
Dosing
See other references for disease specific dosing protocols
Adverse Effects
Alopecia
Fever
Headache
Impaired future fertility
Myelosuppression (with prolonged drop in
CD4 Count
)
Nephrotoxicity
Neurotoxic
Rash
Safety
Avoid in Pregnancy (any trimester)
Use reliable
Contraception
Avoid in
Lactation
Monitoring
Complete Blood Count
Renal Function
tests
Resources
Cladribine (DailyMed)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a2592a9b-bca6-4a5a-89c2-855a0634d5fe
Type your search phrase here