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Mycosis Fungoides

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Mycosis Fungoides, Cutaneous T-Cell Lymphoma, Sezary Syndrome, Sezary Cell, Sezary Erythroderma

  • Pathophysiology
  1. T-Cell Lymphoma that begins in skin
  2. Sezary Syndrome is leukemic form of T-Cell Lymphoma
  • Epidemiology
  1. Incidence: 0.42 cases per 100,000 (rare)
  2. Most common after age 50 years
  3. Gender: Twice as common in men
  4. Black patients are more commonly affected
  • Symptoms
  1. Pruritus
  • Signs (four stages of development)
  1. Eczematous patches and Plaques
  2. Distributed over non-sun-exposed skin
    1. Buttocks
    2. Thighs
  3. Tumors develop later in course
    1. Associated with superficial and deep Lymphadenopathy
    2. Associated with metastases to Spleen, lung, GI Tract
  • Complications
  1. Exfoliative Dermatitis
  • Course
  1. Survival <3 years after tumors develop
  • References
  1. Habif (1996) Clinical Dermatology, Mosby, p. 674-5
  2. Pujol (2000) J Am Acad Dermatol 42:324-8 [PubMed]