- Synthetic guanosine analog antimetabolite
- Thioguanine is phosphorylated by HGPRT (hypoxanthine-guanine phosphoribosyltransferase)
- Incorporated into DNA and RNA in place of guanosine
- Inhibits DNA and RNA synthesis
- Inhibits GPAT (Glutamine-5-phosphoribosylpyrophosphate amidotransferase)
- Inhibits Purine synthesis
- Thioguanine 40 mg scored tablets
- See other references for disease specific dosing protocols
-
Alopecia
- Hepatotoxicity
-
Hyperuricemia
- Myelosuppression
- Thioprine-Related Toxicity (Severe)
- Associated with NUDT15 Gene Anomaly (Nudix Hydrolase 15 deficiency)
- Avoid in Pregnancy (any trimester)
- Use reliable Contraception
- Avoid in Lactation
- Monitoring
- Complete Blood Count
- Liver Function Tests
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