- See Fluoroquinolone
-
Myasthenia Gravis (exacerbates motor weakness)
- See Fluoroquinolone
- Similar activity to Ciprofloxacin (but without Pseudomonas coverage)
- Complicated Urinary Tract Infection
- Take 200 mg orally twice daily for 10 days
-
Chronic Bacterial Prostatitis or Epididymitis (non-STI, not FDA approved)
- Take 300 mg orally twice daily for up to 6 weeks
-
Traveler's Diarrhea
- Take 300 mg orally twice daily for 1 to 3 days
-
Renal Dosing
- eGFR 20 to 50 ml/min: Take typical dose every 24 hours
- eGFR <20 ml/min: Take 50% of typical dose every 24 hours
- See Fluoroquinolone
-
Fluoroquinolones have several serious warnings (e.g. tendon rupture, Neuropathy, Aortic Dissection)
-
QTc Prolongation
-
Hypersensitivity
- Gastrointestinal symptoms (Vomiting, Anorexia)
-
Pruritus
-
Dysgeusia
- Other uncommon effects
- Vasculitis (rare)
- Increased serum transaminases
- White cell findings (lymphocytopenia, Eosinophilia)
- Urine changes (glucosuria, Proteinuria, Hematuria, pyuria)
- Avoided in pregnancy (despite pregnancy Category C)
- Cartilage damage risk
- Considered safe in Lactation
- However, risk of pediatric Arthropathy
-
Bioavailability 98%
- Peaks 1 to 2 hours after oral dose
- Serum Half-Life: 5 to 8 hours (twice as long as Ciprofloxacin)
- Renal excretion (70 to 80% unchanged, remainder to minor, relatively inactive metabolites)
-
Protein binding 30%
- Broad Distribution
-
Warfarin
- Ofloxacin potentiates Anticoagulant activity
- Drugs that interfere with Ofloxacin absorption (give at least 2 hours before or after Ofloxacin)
- Antacids containing Calcium, aluminum or Magnesium
- Sucralfate
- Iron
- Zinc
-
Opiate urine screening
- False Positive
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