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Cefotaxime

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Cefotaxime, Claforan

  • See Also
  1. Third Generation Broad-Spectrum Cephalosporin
  2. Cephalosporin
  3. Ceftriaxone
  4. Cefixime
  5. Cefpodoxime
  6. Cefdinir
  7. Ceftriaxone
  • Indications
  1. Pneumonia
  2. Pyelonephritis
  3. Pelvic Inflammatory Disease
  4. Sepsis
  5. Neonatal Sepsis
  6. Meningitis
  7. Skin and Soft Tissue Infections
  8. Bone and Joint Infections
  9. Intraabdominal infections
  10. Gonorrhea
  • Mechanism
  1. See Third Generation Broad-Spectrum Cephalosporin
  2. Cefotaxime has the more Staphylococcus aureus and Anaerobic activity than Ceftriaxone
  • Dosing
  1. Precautions
    1. Bolus dosing via Central Line risks Arrhythmia
  2. Adult
    1. Standard
      1. Give 1 to 2 g IM or IV every 12 hours (every 8 hours in severe infections)
    2. High Dose (Life threatening infections or Meningitis)
      1. Give 2 g IV every 4 to 6 hours
  3. Child
    1. Newborns
      1. Give 50 mg/kg/dose IV every 12 hours for age <7 days
      2. Give 50 mg/kg/dose IV every 8 hours for age 1 to 4 weeks
    2. Mild to Moderate Infections
      1. Give 75 to 100 mg/kg/day IM or IV divided 6 to 8 hours
    3. Severe Infections
      1. Give 150 to 200 mg/kg/day IM or IV divided 6 to 8 hours
    4. Meningitis (for Streptococcus Pneumoniae)
      1. Give 225 to 300 mg/kg/day IV divided every 6 to 8 hours
    5. Maximum
      1. Limit to 2 g/dose
  4. Renal Dosing
    1. eGFR <20 ml/min: Decrease usual dose by 50%
  • Safety
  1. Pregnancy Category B
  2. Safe in Lactation
  • Resources
  1. Cefotaxime (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ed23b6bc-32c7-4c50-a53d-313ae78e5623
  • References
  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  2. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins