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Cefpodoxime

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Cefpodoxime, Cefpodoxime Proxetil, Vantin

  • See Also
  1. Third Generation Broad-Spectrum Cephalosporin
  2. Cephalosporin
  • Indications
  1. Acute Exacerbation of Chronic Bronchitis
  2. Community Acquired Pneumonia
  3. Urinary Tract Infection
  4. Streptococcal Pharyngitis
  5. Otitis Media
  6. Acute Sinusitis
  • Mechanism
  1. See Third Generation Broad-Spectrum Cephalosporin
  2. Good activity Gram Positive organisms
    1. Covers Staphylococcus aureus
    2. Covers Pneumococcus
  • Medications
  1. Suspension: 50 or 100 mg/5ml
    1. Stable for 14 days in refrigerator
  2. Tablets: 100 or 200 mg
    1. Take with food
  • Dosing
  1. Adult (and age >=12 years)
    1. Streptococcal Pharyngitis, Simple Urinary Tract Infection
      1. Take 100 mg orally twice daily
    2. Acute Exacerbation of Chronic Bronchitis, Community Acquired Pneumonia, Acute Sinusitis
      1. Take 200 mg orally twice daily
    3. Skin Infection
      1. Take 400 mg orally twice daily
  2. Child (age <12 years)
    1. Give 5 mg/kg/dose orally twice daily
  3. Renal Dosing
    1. eGFR <30 ml/min
      1. Decrease dosing frequency to every 24 hours
    2. Hemodialysis
      1. Give after Hemodialysis 3 times per week
  • Safety
  1. Pregnancy Category B
  2. Safe in Lactation
  • Drug Interactions
  1. Antacids (reduce absorption)
    1. Take Cefpodoxime at least 2 hours before or 2 hours after
  • Resources
  1. Cefpodoxime (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c36f2137-98bb-4583-89f7-6bce9582c465
  • References
  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  2. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins