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Progestin Androgenic Activity

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Progestin Androgenic Activity, Androgenic Activity

  • See Also
  1. See Adjunctive Acne Vulgaris Management (low androgen)
  2. Oral Contraceptive
  3. Progestin
  • General
  1. Unbound Testosterone increases with androgenicity
  • Characteristics
  1. Conditions associated with high Androgenic Activity
    1. Acne Vulgaris
    2. Hirsutism
    3. Polycystic Ovary Syndrome (PCOS)
    4. Obesity (or weight gain)
    5. Nervousness
    6. Lowered HDL-2
  2. Conditions associated with low Androgenic Activity
    1. Decreased libido
  • Progestins with most potent Androgenic Activity
  1. Methyltestosterone (50): Upper limit reference
  2. Gestodene (8.6)
  3. Levonorgestrel (8.3)
  4. dl-Norgestrel (4.2)
  5. Desogestrel (3.4)
  • Progestins with least Androgenic Activity
  1. Pregnane Progestin (0)
  2. Norethynodrel (0)
  3. Ethynodiol Diacetate (0.6)
  4. Norethindrone (1.0): Lower limit reference
  • Oral Contraceptive Androgenic Activity (low to high)
  1. Andogen activity based on Methytestosterone mg/28 days
  2. Ortho Tri-Cyclen (Norgestimate): 0.15
  3. Ortho-Cept or Desogen (Desogestrel): 0.17
  4. Modicon (Norethindrone): 0.17
  5. Ortho-Cyclen (Norgestimate): 0.18
  6. Demulen 1/35 (Ethynodiol Diacetate): 0.21
  7. Ortho-Novum 777 (Norethindrone): 0.25
  8. Triphasil (Levonorgestrel): 0.29
  9. Alesse (Levonorgestrel): 0.31
  10. Ortho-Novum 1/35 (Norethindrone): 0.34
  11. Nordette (Levonorgestrel): 0.46
  12. Lo-Ovral (Norgestrel): 0.46
  13. Estrostep (Norethindrone Acetate): 0.53
  14. Loestrin 1/20 (Norethindrone Acetate): 0.53
  15. Loestrin 1.5/30 (Norethindrone Acetate): 0.80
  • References
  1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
  2. Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
  3. Dickey (1998) Managing Contraceptive Pill Patients