Obesity
Obesity
search
Obesity
, Overweight
See Also
Obesity in Children
Obesity Evaluation
Obesity Measurement
(or
Obesity Screening
)
Obesity Risk
(or
Obesity Comorbid Conditions
)
Obesity Management
Obesity Medication
Dietary Supplements in Obesity
Exercise in Obesity
Obesity Resources
Epidemiology
Prevalence
: 33% US adults age 20 to 74 are obese
Trends
Obesity
Prevalence
has increased 8% since 1980
Obesity
Prevalence
has increased 54% ages 6-11 years
Patients gain 1 pound per year after age 25
Grading
BMI 25 to 30: Overweight
BMI 30 to 35: Class 1 Obesity
BMI 35 to 40: Class 2 Obesity
BMI >40: Class 3 Obesity (Severe Obesity)
Pathophysiology
Fat expands in 2 ways
Fat Cell Number
Fat cell number does not decrease with weight loss
Increases 5 fold until age 22 years
Increase continues with nutritional excess
Non-obese person has 25-30 billion fat cells
Obese person has 260 billion cells
Fat Cell Size
Fat cell size reduces with weight loss
Adults fill existing fat cells when they over eat
Evaluation
See
Obesity Evaluation
See
Obesity Measurement
See
Obesity Risk
Diagnosis
Obesity
Men: 20% over estimated
Ideal Weight
Women: 30% over estimated
Ideal Weight
Management
See
Obesity Management
See
Obesity Medication
s
See
Obesity Resources
Worksheets
Dietician in the Box
PreventEdWeightLoss2Sjm.htm
Research
Obesity
Gene
(ob)
Ob expression
Feeding turns on rat adipocytes via
Insulin
Inhibit Neuropeptide Y synthesis at appetite center
Neuropeptide Y
Decreases thermogenesis
Increases
Insulin
and appetite
Ob gene function: Produces
Leptin
(
Protein
)
Leptin
uppresses appetite in rats
Leptin
increases thermogenesis in rats
Leptin
decreases
Insulin
levels in rats
References
Saladin (1995) Nature 377:527-9 [PubMed]
Stephens (1995) Nature 377:530-2 [PubMed]
Pelleymounter (1995) Science, 269(5223):540-3 [PubMed]
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