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Clonidine Overdose

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Clonidine Overdose, Clonidine Toxicity, Clonidine Poisoning

  • See Also
  1. Clonidine
  2. Drug Overdose
  3. Alpha Adrenergic Central Agonist
  4. Clonidine Withdrawal
  • Findings
  • Signs and Symptoms
  1. Apnea
  2. Bradycardia
  3. Coma
  4. Hypertension or Hypotension
  5. Hypothermia
  6. Mental status change
  7. Pinpoint pupils (Miosis)
  8. Respiratory Depression
  • Management
  • Adults
  1. ABC Management
  2. Naloxone
    1. Indicated in respiratory depression and apnea or significant CNS depression
    2. Initial
      1. No respiratory depression: 0.1 to 0.4 mg IV or IM
      2. Respiratory depression: 1 to 2 mg IV or IM
    3. Next, if no response or incomplete response
      1. Give 2 mg IV or IM every 3-5 minutes to a total of 10 mg total maximum
      2. Redosing may be needed due to short naloxone Half-Life
  3. Atropine
    1. Indicated in severe Sinus Bradycardia
    2. Atropine 0.5 to 1 mg IV (may repeat after 3 to 5 min, up to a maximum total dose of 3 mg)
  4. Vasopressors
    1. Indicated for Hypotension refractory to Intravenous Fluids
    2. Norepinephrine or Epinephrine IV
  • Management
  • Children
  1. ABC Management
  2. Naloxone
    1. Initial
      1. No respiratory depression: 0.1 mg/kg to 0.4 mg IV or IM
      2. Respiratory depression: 1 to 2 mg IV or IM
    2. Next, if no response or incomplete response
      1. Give 2 mg IV or IM every 3-5 minutes to a total of 10-20 mg
  3. Atropine
    1. Indicated in Severe Bradycardia
    2. Start: Atropine 0.02 mg/kg up to 0.16 mg IV
    3. Maximum: Atropine 0.5 mg/kg IV
  4. Vasopressors
    1. Indicated for Hypotension refractory to Intravenous Fluids
    2. Norepinephrine or Epinephrine IV
  • References
  1. Seger (2002) J Toxicol Clin Toxicol 40(2): 145-55 [PubMed]