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Depression Provoking Medications

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Depression Provoking Medications, Medications Predisposing to Depression, Medication Causes of Depression, Suicidality Associated with Medications

  • Causes
  • Suicidality Associated with Medications
  1. Varenicline (Chantix)
  2. Anticonvulsants
  3. Antidepressants in teens
  4. Singulair is being investigated for possible increased Suicidality
    1. (2008) Prescriber's Letter 15(5): 27-8
  5. Accutane does not appear to increase risk despite early reports
    1. Marqueling (2007) Semin Cutan Med Surg 26(4):210-20 [PubMed]
  1. Alcohol Abuse
  2. Benzodiazepine
  3. Barbiturate
  4. Narcotic or opiate Intoxication
  5. Amphetamine withdrawal
  6. Cocaine withdrawal
  7. Anabolic Steroid use
  8. Phencyclidine (PCP)
  9. Marijuana
  1. Highest risk
    1. Beta Blockers (Propranolol)
    2. Reserpine (Depletes Catecholamines)
    3. Methyldopa (Depletes Catecholamines)
  2. Low risk
    1. Clonidine (Catapres)
    2. Thiazide Diuretics
    3. Guanethidine
    4. Prazosin
    5. Hydralazine
  3. No risk
    1. ACE Inhibitors
    2. Calcium Channel Blockers
    3. Diuretics
  • Causes
  • Gastrointestinal agents
  1. Metoclopramide (Reglan)
  2. Ranitidine
  3. Cimetidine
  • Causes
  • Chemotherapeutic medications
  1. 6-Azauridine
  2. Asparaginase
  3. Azathioprine (Imuran)
  4. Bleomycin
  5. Cisplatin
  6. Cyclophosphamide
  7. Doxorubicin
  8. Mithramycin
  9. Vinblastine
  10. Vincristine
  • Causes
  • Neurologic Agents
  1. Anti-parkinsonian Medications
    1. Amantadine
    2. Bromocriptine
    3. Levodopa
  2. Anti-Seizure Medications
    1. Carbamazepine (Tegretol)
    2. Ethosuximide (Zarontin)
    3. Phenobarbital
    4. Phenytoin (Dilantin)
    5. Primidone
  • Causes
  • Psychotropic agents
  1. Catecholamine receptor blockers
    1. Fluphenazine (Prolixin)
    2. Haloperidol (Haldol)
  2. Sedatives
    1. Barbiturates
    2. Benzodiazepines
  • Causes
  • Other medications
  1. Baclofen
  2. Cycloserine
  3. Disulfiram (Antabuse)
  4. NSAIDs
  5. Sulfonamides
  6. Corticosteroids
  7. Digitalis Glycosides (Digoxin)
  8. Oral Contraceptives
  9. Isoniazid
  10. Montelukast (Singulair)
  • References
  1. Beers (1990) Drugs 40(6):792-9 [PubMed]
  2. Citrome (1994) Postgrad Med, 95(1): 137-45 [PubMed]
  3. Ferris (1995) Depression Primary Care, PGM, p.36-44
  4. Kuzel (1996) Postgrad Med, 99(5): 179-95 [PubMed]