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Fluphenazine

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Fluphenazine, Prolixin, Modecate

  • See Also
  1. Antipsychotic
  2. Psychosis
  • Mechanism
  1. Phenothiazine
  2. Potent Dopamine D2 Receptor Antagonist
  1. Adult IM or Oral Immediate Formulation
    1. Start 2.5 mg IM or orally twice daily
    2. Titrate to 10 mg/day IM or 20 mg/day orally divided every 6 to 8 hours
    3. Maximum Dose: 40 mg
  2. Depot IM/SC Long Acting Formulation (Fluphenazine enanthate, Fluphenazine decanoate)
    1. Stabilize on oral dose before initiating depot dose
    2. Start 12.5 to 25 mg IM or SQ every 4 to 6 weeks (equivalent to 10 to 20 mg/day of oral dose)
  • Adverse Effects
  1. Akathisia
  2. Parkinsonism
  3. Dystonia
  4. Hyperprolactinemia
  • Safety
  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation
  • Resources
  1. Fluphenazine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=50c7e742-1165-4c45-bbf6-172cf70a387a
  • References
  1. (2016) Med Lett Drugs Ther 58(1510): 160-5
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 42-3
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia