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Vinblastine

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Vinblastine

  • See Also
  1. Vincristine
  2. Vinorelbine
  3. Mitotic Inhibitor Chemotherapy
  4. Chemotherapy
  • Indications
  1. FDA Approved
    1. Breast Cancer
    2. Choriocarcinoma
    3. Kaposi Sarcoma
    4. Histiocytosis X
    5. Lymphoma (Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Histiocytic Lymphoma, Cutaneous T-Cell Lymphoma)
    6. Testicular Cancer (advanced)
  2. Off-Label
    1. Bladder Cancer
    2. Melanoma
    3. Non-Small Cell Lung Cancer
    4. Soft Tissue Sarcoma
  • Mechanism
  1. See Mitotic Inhibitor Chemotherapy
  2. Vinblastine, like Vincristine, is a natural Vinca Alkaloid with antineoplastic activity
    1. Isolated from the periwinkle plant (Vinca rosea Linn)
  3. Vinblastine is antitubular agent
    1. Binds tubulin and inhibits microtubule formation
    2. Disrupts mitotic spindle formation
    3. Arrests Cell Cycle in M phase
  4. Other possible activity
    1. Interferes with metabolism of Amino Acids cAMP, glutathione
    2. Interferes with calmodulin-dependent Calcium transport ATPase activity
    3. Interferes with biosynthesis of Nucleic Acids and lipids
  • Medications
  1. Vinblastine injection solution: 1 mg/ml in 10 mg vials
  • Dosing
  1. See other references for disease specific dosing protocols
  • Adverse Effects
  1. Impaired future fertility
  2. Alopecia
  3. Bronchospasm
  4. Severe skin and soft tissue necrosis on extravasation
    1. Vinblastine is a strong Vesicant (causes Blistering)
  5. Peripheral Neuropathy
    1. Less than Vincristine
  6. Myelosuppression (Bone Marrow suppression)
    1. Leukopenia
    2. More myelosuppression than Vincristine
  • Safety
  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception
  • Drug Interactions
  1. Drug levels decreased by Vinblastine
    1. Phenytoin
  2. Increased Vinblastine levels and toxicity
    1. CYP3A4 Inhibitors (e.g. Ketoconazole, Erythromycin)
  • Resources
  1. Vinblastine Sulfate Injection (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f073b58e-56d6-4c8d-a2ce-b37719402d77
  • References
  1. Dhyani (2022) Cancer Cell Int 22(1):206 +PMID: 35655306 [PubMed]
    1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161525/