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Mitotic Inhibitor Chemotherapy

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Mitotic Inhibitor Chemotherapy, Mitosis Inhibitor Anticancer Agent, Mitosis Inhibitor, Antimicrotubular Agent, Antimitotic Agent, Plant Alkaloid Chemotherapy, Vinca Alkaloid, Taxane, Topoisomerase Inhibitor

  • See Also
  1. Antimetabolite Chemotherapy
  2. Chemotherapy
  • Medications
  • Mitotic Inhibitors
  1. Vinca Alkaloids
    1. Vinblastine (Velban)
    2. Vincristine (Oncovin)
    3. Vinorelbine
  2. Taxanes
    1. Paclitaxel (Taxol)
    2. Albumin-Bound Paclitaxel (Abraxane)
    3. DocetaxelTaxotere (Taxotere)
    4. Cabazitaxel (Jevtana)
  3. Topoisomerase 1 Inhibitors
    1. Topotecan (Hycamptin)
    2. Irinotecan (Camtosar)
    3. Irinotecan Liposome (Onivyde)
  4. Topoisomerase 2 Inhibitors
    1. Anthracyclines (e.g. Daunorubicin, Doxorubicin, Idarubicin, Mitoxantrone)
    2. Etoposide (VePesid, VP-16)
    3. Teniposide (Vumon, VM-26)
  5. Other
    1. Ixabepilone (Ixempra)
    2. Eribulin
  • Medications
  • Plant-Based Alkyloids
  1. Subset of the mitotic inhibitors listed above
  2. Vinca Alkaloids
    1. Inhibits mitosis (metaphase arrest)
    2. Cause disassembly of microtubules
    3. Periwinkle Plant (Vinca rosea) derivatives include Vinblastine and Vincristine
  3. Podophyllotoxins
    1. Block cells in S-G2 phase of cell cycle
    2. DNA degradation
    3. Nucleoside transport inhibition
    4. Mitochondrial electron transport inhibition
    5. Mayapple plant (Podophyllum peltatum) derivatives include Etoposide and Teniposide