Bronchi

Bronchiolitis Obliterans

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Bronchiolitis Obliterans

  • See Also
  1. Bronchiolitis Obliterans with Organizing Pneumonia
  • Pathophysiology
  1. Obstruction of Bronchioles by granulation tissue
  2. Triggered by injury to Bronchiolar epithelium
    1. Response to Bronchiolar reinjury during repair phase
    2. Results in excessive granulation tissue proliferation
  • Causes
  1. Inhalation of toxic fumes
  2. Exposure to mineral dust
  3. Transplantation
    1. Bone Marrow Transplant with graft-versus-host disease
    2. Heart-Lung Transplantation
  4. Hypersensitivity pneumonitis
  5. Medications: Penicillamine
  6. Infection
    1. Mycoplasma pneumoniae
    2. Legionella
    3. Viral respiratory infections
  7. Rheumatologic Conditions
    1. Rheumatoid Arthritis
    2. Systemic Lupus Erythematosus
    3. Dermatomyositis
    4. Polymyositis
  • Symptoms
  1. Non-productive cough with Dyspnea
  2. Onset 2-8 weeks after respiratory injury (see causes)
  • Signs
  1. Expiratory Wheezes
  1. Variable pattern (may be normal)
  2. Diffuse nodular pattern
  3. Distal hyperinflation