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Bone Marrow Transplant

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Bone Marrow Transplant

  • See Also
  1. Transplantation
  2. Hemopoietic Stem Cell Transplant
  • Complications
  • Infection
  1. T Cells function poorly after transplant for the first 100 days
    1. Higher risk of Viral Infection during this time
  2. Infections otherwise follow a pattern based on time from transplant that is similar to Solid Organ Transplant
    1. Month 1: Nosocomial infection (e.g. CAUTI, VAP, SSI)
    2. Month 1-6: Opportunistic infection (CMV, EBV, fungal and Parasitic Infections, Tuberculosis)
    3. Month 6+: Community acquired infection (e.g. Pneumonia) and opportunistic infections
  • Complications
  • Allogenic - Early (first year)
  1. Graft-versus host (severe active, higher risk)
  2. Chronic Diarrhea, malabsorption and Electrolyte abnormalities
  3. Hemorrhagic cystitis
    1. Risk of Acute Renal Failure
    2. Initiate IV fluids
    3. Obtain renal Ultrasound
  • Complications
  • Allogenic - Late (10 years post transplant)
  1. Graft-versus-host (chronic, residual)
  2. HPV-mediated oropharyngeal cancer
  3. Lung disease
  4. Growth Hormone Deficiency with Short Stature
  5. Hypogonadism
  6. Hypothyroidism
  7. Basal Cell Carcinoma
  8. Cirrhosis
  • References
  1. Bhatia and Claudius in Herbert (2013) EM:Rap 13(6): 6-7
  2. Claudius, Ruttan and DeFabio in Swadron (2022) EM:Rap 22(11): 13
  3. Bhatia (2012) Pediatrics 130(6): 1141-3 [PubMed]