Fever

Fever of Unknown Origin Examination

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Fever of Unknown Origin Examination

  • See Also
  1. Fever
  2. Fever of Unknown Origin
  3. Fever of Unknown Origin History
  4. Drug-Induced Fever
  5. Fever of Unknown Origin Causes
  6. Fever of Unknown Origin Causes by Age
  7. Fever in the Returning Traveler
  8. Fever of Unknown Origin Causes in Comorbid Conditions
  9. Fever of Unknown Origin History
  • Signs
  • Skin findings suggestive of infectious pathology
  1. Petechiae or Purpura (Systemic Vasculitis)
  2. Seborrheic rash (Histiocytosis X)
  3. Perineal rash (Kawasaki's Disease)
  4. Pallor, Jaundice or soft skin (Hyperthyroidism)
  5. Sparse eyebrows (anhydrotic ectodermal dysplasia)
  6. Hair Loss or breakage (Systemic Lupus Erythematosus)
  7. Characteristic rashes
    1. Tick-borne infection (e.g. Erythema Migrans in Lyme Disease)
    2. Herpes Simplex Virus
    3. Systemic Lupus Erythematosus (e.g. Malar Rash)
    4. Sarcoidosis (e.g. Lupus Pernio, Dactylitis, Erythema Nodosum)
    5. Still's Disease
      1. Faint salmon colored rash over trunk, palms and soles
  8. Oral Ulcers
    1. Behcet Disease
    2. Systemic Lupus Erythematosus
  • Signs
  • Eye findings suggestive of infectious pathology
  1. Bulbar Conjunctivitis
    1. Kawasaki's Disease
    2. Leptospirosis
  2. Palpebral or Bulbar injection
    1. Systemic Lupus Erythematosus
    2. Tularemia
    3. Histoplasmosis
    4. Chlamydia
  3. Punctate Conjunctival Hemorrhages
    1. Bacterial Endocarditis
  4. No pupillary constrictor response
    1. Familial Dysautonomia
  5. Fundus lesions
    1. Toxoplasmosis
    2. Cytomegalovirus
    3. Papilledema
    4. Roth Spots
    5. Leptospirosis
  6. Uveitis
    1. Autoimmune Disease
    2. Sarcoidosis
    3. Tuberculosis
    4. Toxoplasmosis
    5. Syphilis
    6. Leptospirosis
    7. Still's Disease
  1. Alcoholic Liver Disease or Cirrhosis
  2. Cancer (e.g. Hepatic Malignancy or Liver Metastases, Renal Mass)
  3. Cytomegalovirus
  4. Epstein-Barr Virus
  5. Leukemia
  6. Lymphoma
  7. Miliary Tuberculosis
  8. Q Fever (Hepatomegaly)
  • Signs
  • Musculoskeletal findings
  1. Joint Swelling or pain
    1. Inflammatory Bowel Disease
    2. Lyme Disease
  2. Bone findings suggestive of infectious pathology
    1. See Osteomyelitis
    2. See Vertebral Osteomyelitis
    3. Focal tenderness (assess for long bone Osteomyelitis)
  • Signs
  • Lymph Node findings suggestive of infectious pathology
  1. Generalized Lymphadenopathy
    1. Autoimmune cause (e.g. Rheumatoid Arthritis, Systemic Lupus Erythematosus, Sarcoidosis)
    2. Cat Scratch Disease
    3. Cytomegalovirus
    4. Epstein-Barr Virus
    5. Acute HIV Infection
  2. Localized or nontender adenopathy
    1. Malignancy
  • Signs
  • Cardiac findings suggestive of infectious pathology
  1. Diastolic insufficiency murmurs
  2. Widened Pulse Pressure
  • References
  1. David (2022) Am Fam Physician 105(2): 137-43 [PubMed]